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American Journal of Clinical Nutrition, 1996; 64: 515S-518S.
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Use of bioelectrical impedance analysis measurements in patients with diabetes.

Lawrence A. Leiter and the Diabetes Control and Complications Trial Research Group.
Weight gain is an important consequence of the intensive treatment of
insulin-dependent diabetes mellitus (IDDM). Despite this, body composition
in this disorder has not been well studied. Bioelectrical impedance analysis
(BIA) has been shown to be a reliable, noninvasive method of assessing body
composition but little is known about its use in IDDM. Therefore, a
regression model estimating fat-free volume mass from bioelectrical
impedance measurements obtained with proximal electrode placements was
developed in 46 adults with IDDM through use of dual-energy X-ray
absorptiometry (DXA) for reference values of fat- free mass. No effect of
blood glucose concentration or prandial state on the impedance
characteristics was observed. A regression model was developed incorporating
the ratio of height squared to the minimum resistance of four limb-lead
combinations (H**2/R), total body weight, and a weight-sex interaction. With
this model, BIA correlated closely with DXA (R**2 = 0.982, residual SD = 1.3
kg). The applicability of these equations to non-insulin-dependent diabetes
mellitus is unknown.
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