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Current Therapeutic Research,
Volume 59, No. 11, November 1998:793-802.

Effect of pyruvate supplementation on
body composition and mood.

Douglas Kalman (1), Carlon M. Colker (1), Robert Stark (2), Alisa Minsch (1), Ilene Wilets (3), and Jose Antonio (4).

(1) Peak Wellness, Greenwich, Connecticut, (2) Department of Cardiology, Greenwich Hospital, Greenwich, Connecticut, (3) Department of Biostatistics, Beth Israel Medical Center, New York, New York, and (4) University of Nebraska, Human Performance Laboratory, Kearney, Nebraska.

Abstract: A 6-week, double-masked, placebo-controlled study was conducted to determine the effects of pyruvate supplementation on body weight, body composition, and vigor and fatigue levels in overweight men and women. Subjects were separated into one of three groups: pyruvate (6 g/d), placebo (maltodextrin 6 g/d), and control (received nothing). In addition, each subject participated in a circuit weight training and aerobic exercise program three times per week, 45.5 minutes per day. After 6 weeks of treatment, a significant decrease in fat mass (2.1 kg) and percent body fat (2.6%), and a significant increase in lean body mass (1.6 kg) were noted in the pyruvate group. The placebo and control groups did not demonstrate significant changes in fat mass, percent body fat, or lean body mass. In addition, profile of Mood States-fatigue scores decreased significantly after 6 weeks in the pyruvate and placebo groups; Profile of Mood States-vigor scores increased significantly only in the pyruvate group. The ingestion of pyruvate 6 g/d for 6 weeks, along with regular exercise, can reduce body fat, increase lean body mass, and improve fatigue and vigor scores.
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